News Letter

A plain-language patient guide to Kisspeptin-10 — how this master hormone signal works, what conditions it may support, how it compares to TRT and HCG, and what the research says about safety and dosing.

A Precision Aging Review of Two of the Most Discussed Peptides in Longevity Medicine

Unlocking the Science Behind Biological Age and Precision Aging By Bio Precision Aging Reading Time: 4 minutes What Is Methylation? Methylation is a fundamental biochemical process in the human body. At its core, methylation involves the transfer of a methyl group (CH₃) onto DNA, proteins, or other molecules, thereby regulating gene expression — determining which genes are activated or silenced — without altering the underlying DNA sequence, a mechanism known as epigenetic re

A Bio Precision Aging Executive Brief Read time - 4 minutes A Structural Risk Interception Framework For high-performing professionals in their mid-40s, health risk rarely announces itself with symptoms. Atherosclerosis progresses silently. Adenomas evolve over a decade. Malignancies can grow undetected for years before crossing a clinical threshold. Advanced screening is not a substitute for primary care. It is layered risk interception. Laboratory biomarkers assess metaboli

A Bio Precision Aging Evidence-Based Brief Read time - 3 Minutes   T he original shingles vaccine—Zostavax—was a live-attenuated vaccine designed to reduce the risk of shingles (herpes zoster) and its most feared complication, long-lasting nerve pain called postherpetic neuralgia. In the U.S., Zostavax has largely been replaced by the newer recombinant vaccine Shingrix, which is more effective for shingles prevention.  What’s changed recently is that shingles vaccination is n

A Bio Precision Aging Evidence-Based Brief Introduction Colorectal cancer was once considered a disease of older age. For decades, incidence rose slowly with aging and then declined as screening improved. That pattern has changed. Over the past 20 years, colorectal cancer rates have increased steadily among adults under 50, including people in their 30s and early 40s. This shift has caught both clinicians and the public off guard, because it is occurring in individuals who of

A Bio Precision Aging Evidence-Based Brief for Executives and Professionals Reading time: ~3minutes Rethinking the Food Pyramid for Longevity For decades, the classic food pyramid has been a staple in nutrition education, but it was built for a world where food scarcity was the main concern. That paradigm emphasized calorie sufficiency, widespread availability, and population-level safety—goals that made sense in a different era. Today, professionals live in an environment of

A Bio Precision Aging Evidence-Based Brief Reading time: ~3minutes What You’ll Gain If you’re seeking clarity on how artificially sweetened beverages affect core biomarkers linked to metabolic health and longevity, this article offers a grounded understanding of the risk versus reward—far beyond “zero calories” marketing. You’ll come away with realistic expectations about who is most affected by these beverages and who may see minimal short-term impact. Executive Summary Arti

Sermorelin: What It Actually Does—and Why Expectations Matter A Bio Precision Aging Evidence-Based Brief for Executives and Professionals Reading time: ~ 3 minutes What You’ll Gain You’ll gain a clear explanation of what sermorelin is and how it differs from growth hormone, an evidence-based view of which outcomes are realistic versus overstated, how “nearby” GH-axis peptides compare (mechanisms, outcomes, safety), and a practical step-up approach to alternatives when sermore

Raw Milk: What the Science Actually Says—and What Most People Miss A Bio Precision Aging Evidence-Based Brief for Executives and Professionals Reading time: ~3 minutes What You’ll Gain ·      A clear understanding of what raw milk is—and what it is not ·      An evidence-based view of proposed benefits vs. proven risks ·      Context to make an informed decision without fear-based or influencer-driven narratives Executive Summary Raw milk has become a cultural lightning rod—p

A Bio Precision Aging Evidence-Based Implementation Guide Reading Time: 6 minutes  |  Implementation Time: 12 weeks to full integration What You’ll Gain Measurable reduction in infection frequency: 28-46% fewer upper respiratory infections within 3-6 months based on combined lifestyle interventions Faster recovery from illness: 1-2 days shorter duration when infections do occur, supported by improved immune cell function Sustained immune resilience: Maintained T-cell and nat

By Bio Precision Aging Team Y ou’re training consistently. Watching your diet. Hitting the gym three to four times a week with legitimate effort—yet your body composition hasn’t changed in two years. Not declined. Just… stopped responding. I lived this for the better part of three years in my late 40s. My lifts were solid. Recovery was manageable. But the lean mass improvements I’d experienced earlier simply plateaued. No matter how precise I got with volume, frequency, or in

At 63, maintaining 7% body fat taught me something most people never grasp: excess body fat isn’t just storage—it’s an active metabolic weapon systematically dismantling your cardiovascular infrastructure. The 2024 European Heart Journal analysis of over 10 million people confirmed what I discovered through rigorous self-experimentation: every incremental 10-pound increase in body fat initiates a quantifiable cascade of inflammatory damage, insulin resistance, and cardiovasc

If you’ve been told you have Hashimoto’s thyroiditis—or suspect you might—you’re not alone. Hashimoto’s is the most common autoimmune disease in the world and the leading cause of hypothyroidism in developed countries. It occurs when the immune system mistakenly targets the thyroid gland, gradually damaging the tissue responsible for producing thyroid hormone. An estimated 5–10% of the population has Hashimoto’s, with women affected 7–10 times more often than men . Even more

W hat does the latest human research really tell us about metabolic health and cognitive aging? For decades, the prevention of cognitive decline has focused almost entirely on the brain itself. Alzheimer’s disease and related dementias were framed as isolated neurological conditions driven by amyloid plaques, tau tangles, and neuronal loss. While these mechanisms remain essential, a growing body of human research suggests that this brain-only model is incomplete. Increasingly

Why Your Brain Doesn’t Care About Your New Year’s Resolution—But Your Identity Does As we move toward the New Year, most people start talking about “getting motivated.” New gym memberships, latest supplements, new planners, new promises. But here’s the uncomfortable truth: Motivation is a myth. At least in the way most people think about it. Your success in 2026 will not depend on motivation. It will depend on identity. And the science is finally catching up to what many tran

Your heart's rhythm holds the secret to your longevity—and most people are measuring the wrong thing. The Science Spotlight: Your Weekly Deep Dive Into Breakthrough Research I spent decades in believing that a low resting heart rate was the gold standard for cardiovascular fitness. I've learned that the real marker of physiological resilience isn't how slow your heart beats—it's how adaptable it is. Heart Rate Variability, or HRV, measures the variation in time between consec

There is no proven casual link between melatonin and heart failure. By Dr. Travis Smith, DO – Bio Precision Aging Medical Editorial Team A recent analysis presented at the American Heart Association (AHA) Scientific Sessions 2025 sparked headlines suggesting that long-term melatonin use may increase the risk of heart failure. But before we draw conclusions, it’s critical to understand what the study actually showed—and what it did not prove. Let’s unpack the findings, the li

By Travis Smith, DO A s physicians working in precision aging and longevity medicine, we’re constantly seeking evidence-based interventions that can meaningfully impact healthspan and lifespan. Recent landmark research from major academic institutions has revealed something remarkable: daily low-dose tadalafil may be one of the most underutilized longevity interventions available today. The Numbers Are Staggering A comprehensive study published in The Journal of Sexual Medic

Your cholesterol might be perfect, but if your hsCRP is above 3 mg/L, your risk of early death just tripled. This blood marker that 90% of people never test could be the difference between thriving at 80 or struggling at 60. A fter decades of monitoring every biomarker I could get my hands on, I've learned that the numbers that matter most aren't always the ones we're watching. Sure, everyone tracks cholesterol and blood sugar. But there's one marker that's been quietly predi