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A precision-medicine review of melatonin's role in circadian aging, sleep architecture, and vascular health, synthesizing RCT and meta-analytic evidence from the Journal of Pineal Research, Sleep Medicine Reviews, Journal of Sleep Research, Cochrane Database of Systematic Reviews, and the International Journal of Molecular Sciences.

A 2023 Science study identified taurine decline as a driver of aging, and roughly 60 pooled human RCTs now show consistent metabolic and cardiovascular benefits. This Executive Brief reviews the mechanisms, evidence, dosing, and safety profile.

Fisetin is the most potent senolytic flavonoid identified to date, extending lifespan in aged mice and now in Phase 2 human trials for sepsis and post-COVID recovery (Yousefzadeh 2018, EBioMedicine; Silva 2024, Trials). This executive brief covers mechanisms, human bioavailability data, dosing, and safety.

A Bio Precision Aging evidence review drawing on Annals of Internal Medicine, JAMA Internal Medicine, Heart Rhythm, GeroScience, and Cancer Causes & Control. Moderate coffee intake (2-4 cups/day) is linked to lower all-cause and cardiovascular mortality, a neutral-to-protective atrial fibrillation association confirmed by Mendelian randomization, neuroprotective mechanisms relevant to Alzheimer's disease, and improved colorectal cancer survival.

More than 38 million Americans live with type 2 diabetes, a condition where the body's fuel system stops working efficiently. Here is what it is, why it happens, and how to manage it well.

VO2 max is a direct, causally-linked predictor of all-cause mortality (an 80% risk difference between fitness extremes, JAMA Network Open 2018), while HRV is a heritable, confounder-sensitive autonomic proxy with a smaller and less consistent link to cardiovascular events (Europace 2013 meta-analysis). This Bio Precision Aging brief compares the evidence and gives a precision testing and training protocol for both.

BEYOND THE HEADLINES Bio Precision Aging — Member Deep Dive Series | August 5 ,2026 You have seen the headlines. “The molecule that could reverse aging.” “The supplement Silicon Valley billionaires take every morning.” “Scientists discover the fountain of youth in a pill.” Type “NAD+” into a search bar and you will drown in miracle claims, glossy influencer ads, and $90 bottles promising to turn back your biological clock. Two names keep surfacing above the noise — NMN and

A physician review of AMPK-activating therapies for metabolic aging: the Bannister mortality cohort (Diabetes Obes Metab, 2014), the Yin head-to-head berberine vs. metformin trial (Metabolism, 2008), and a berberine umbrella review (Phytother Res, 2023) — with dosing, monitoring, and safety guidance.

BIO PRECISION AGING — BEYOND THE HEADLINES The First Cholesterol Pill of Its Kind — and the Confusion It Cuts Through Lipfendra (enlicitide), the first oral PCSK9 inhibitor, and what the cholesterol debate keeps getting wrong · July 22,, 2026 This month the FDA approved Lipfendra (enlicitide), the first once-daily pill to block PCSK9, the protein that governs how aggressively your liver clears cholesterol from your blood. The headlines call it a breakthrough, and in one nar

Rapamycin is the only pharmacological agent proven to reproducibly extend mammalian lifespan across independent labs. This evidence-based executive brief synthesizes 8 peer-reviewed studies — including the 2025 PEARL trial, the first placebo-controlled human healthspan trial — covering mechanism, dosing, monitoring, and safety for precision aging medicine.

Sunscreen is one of the few products in your bathroom with randomized-trial evidence that it prevents cancer. It's also the target of a steady stream of alarming headlines. Both things deserve a closer look. Sunscreen occupies an unusual place in health. Very few consumer products have been tested in a randomized controlled trial and shown to prevent cancer in humans. Sunscreen has. Yet over the past few years it has been battered by headlines about chemicals seeping into the

The longevity advice is to “build muscle.” The research says something more precise—and it changes how you should train. In the late 1990s, researchers recruited roughly 3,000 older adults in Pittsburgh and Memphis and tracked them for years, measuring nearly everything: how much muscle each person carried, how strong they were, how their bodies changed with age. The expectation was straightforward. More muscle should mean a longer life. That isn’t what they found. When the H

The evidence is more substantial than it is for most longevity supplements—but the details matter. By the Bio Precision Aging Editorial Team You can eat well, train consistently and still notice that recovery takes longer, endurance comes less easily and the energy you once took for granted is no longer automatic. That does not always mean you need more motivation. It may mean the machinery inside your cells is becoming less efficient. Most of the cells in your body contain..

Just Happened On June 18, 2026 — during Men's Health Month — the U.S. Department of Health and Human Services (HHS), through the FDA, announced a request for class-wide updates to the prescribing information for all testosterone replacement therapy (TRT) products. These proposed changes represent the most significant regulatory revision to testosterone labeling since 2015 and signal a meaningful shift in how the U.S. government views the evidence base for TRT in aging men. HH