

Melatonin in Aging and Circadian Health: Beyond the Sleep Hormone
A precision-medicine review of melatonin's role in circadian aging, sleep architecture, and vascular health, synthesizing RCT and meta-analytic evidence from the Journal of Pineal Research, Sleep Medicine Reviews, Journal of Sleep Research, Cochrane Database of Systematic Reviews, and the International Journal of Molecular Sciences.
Winston Wilkinson
7 days ago13 min read


Taurine: The Longevity Amino Acid
A 2023 Science study identified taurine decline as a driver of aging, and roughly 60 pooled human RCTs now show consistent metabolic and cardiovascular benefits. This Executive Brief reviews the mechanisms, evidence, dosing, and safety profile.
Winston Wilkinson
7 days ago9 min read


Beyond the Headlines: Fisetin — Can We Really Clear Away the “Zombie” Cells of Aging?
Fisetin is the most potent senolytic flavonoid identified to date, extending lifespan in aged mice and now in Phase 2 human trials for sepsis and post-COVID recovery (Yousefzadeh 2018, EBioMedicine; Silva 2024, Trials). This executive brief covers mechanisms, human bioavailability data, dosing, and safety.
Winston Wilkinson
Aug 2111 min read






