A precision-medicine review of melatonin's role in circadian aging, sleep architecture, and vascular health, synthesizing RCT and meta-analytic evidence from the Journal of Pineal Research, Sleep Medicine Reviews, Journal of Sleep Research, Cochrane Database of Systematic Reviews, and the International Journal of Molecular Sciences.

A 2023 Science study identified taurine decline as a driver of aging, and roughly 60 pooled human RCTs now show consistent metabolic and cardiovascular benefits. This Executive Brief reviews the mechanisms, evidence, dosing, and safety profile.

Fisetin is the most potent senolytic flavonoid identified to date, extending lifespan in aged mice and now in Phase 2 human trials for sepsis and post-COVID recovery (Yousefzadeh 2018, EBioMedicine; Silva 2024, Trials). This executive brief covers mechanisms, human bioavailability data, dosing, and safety.

A Bio Precision Aging evidence review drawing on Annals of Internal Medicine, JAMA Internal Medicine, Heart Rhythm, GeroScience, and Cancer Causes & Control. Moderate coffee intake (2-4 cups/day) is linked to lower all-cause and cardiovascular mortality, a neutral-to-protective atrial fibrillation association confirmed by Mendelian randomization, neuroprotective mechanisms relevant to Alzheimer's disease, and improved colorectal cancer survival.

More than 38 million Americans live with type 2 diabetes, a condition where the body's fuel system stops working efficiently. Here is what it is, why it happens, and how to manage it well.